Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007195)
Formula Reactant Flunitrazepam Product 7-amino-unitrazepam
Reactant Info Product Info
Metabolic Enzyme Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007194 Flunitrazepam 3-hydroxyflunitrazepam Oxidation - Hydrolyzationn Flunitrazepam [1]
MR007193 Flunitrazepam Desmethylflunitrazepam Oxidation - Demethylation Flunitrazepam [1], [2], [3]
References
1 Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):460-5.
2 Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4. Xenobiotica. 1999 Oct;29(10):973-86.
3 Lack of interaction of buprenorphine with flunitrazepam metabolism

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