Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007194)
Formula
SVG example
Hydrolyzationn
Reactant Flunitrazepam Product 3-hydroxyflunitrazepam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007195 Flunitrazepam 7-amino-unitrazepam Reduction - Reduction Flunitrazepam [1], [2], [3]
MR007193 Flunitrazepam Desmethylflunitrazepam Oxidation - Demethylation Flunitrazepam [4], [3], [5]
References
1 Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis. Biochem Pharmacol. 2012 Jun 15;83(12):1690-9.
2 NADPH-cytochrome P-450 reductase is involved in flunitrazepam reductive metabolism in Hep G2 and Hep 3B cells
3 Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4. Xenobiotica. 1999 Oct;29(10):973-86.
4 Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):460-5.
5 Lack of interaction of buprenorphine with flunitrazepam metabolism

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