Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007248)
Formula
SVG example
Reactant ANW-32821 Product 24S-hydroxycholesterol
Reactant Info Product Info
Metabolic Enzyme Cholesterol 24-hydroxylase (CYP46A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007244 ANW-32821 27-hydroxycholesterol Unclear ANW-32821 [1], [2]
MR007246 ANW-32821 7alpha-hydroxycholesterol Unclear ANW-32821 [3]
MR007247 ANW-32821 Pregnenolone Unclear ANW-32821 [3]
References
1 Cholesterol ester oxidation by mycobacterial cytochrome P450. J Biol Chem. 2014 Oct 31;289(44):30417-25.
2 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.
3 Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20.

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