Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007244)
Formula
cyp125A1 ...
SVG example
Reactant ANW-32821 Product 27-hydroxycholesterol
Reactant Info Product Info
Metabolic Enzyme Steroid C26-monooxygenase (cyp125A1) DME Info
Steroid C26-monooxygenase (cyp142A1) DME Info
Cytochrome P450 125A1 (cyp125A1) DME Info
Cytochrome P450 142A1 (cyp142A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007248 ANW-32821 24S-hydroxycholesterol Unclear ANW-32821 [1]
MR007246 ANW-32821 7alpha-hydroxycholesterol Unclear ANW-32821 [1]
MR007247 ANW-32821 Pregnenolone Unclear ANW-32821 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007245 27-hydroxycholesterol Carboxylic acid Unclear ANW-32821 [2], [3]
References
1 Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20.
2 Cholesterol ester oxidation by mycobacterial cytochrome P450. J Biol Chem. 2014 Oct 31;289(44):30417-25.
3 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.

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