Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007381)
Formula
CYP1A1 ...
SVG example
Reactant BS-3952 Product S-(+)-4-hydroxydebrisoquine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007382 BS-3952 5-hydroxydebrisoquine Unclear BS-3952 [1]
MR007377 BS-3952 6-hydroxydebrisoquine Unclear BS-3952 [1]
MR007379 BS-3952 7-hydroxydebrisoquine Unclear BS-3952 [1]
MR007383 BS-3952 8-hydroxydebrisoquine Unclear BS-3952 [1]
MR007384 BS-3952 BS-3952 M1 Unclear BS-3952 [2]
MR007385 BS-3952 BS-3952 M2 Unclear BS-3952 [2]
References
1 Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes
2 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. J Pharmacol Exp Ther. 2002 Jun;301(3):1025-32.

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