Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007387)
Formula
SVG example
N-desethylation
Reactant CBL-0102 M2 Product CBL-0102 M3
Reactant Info Product Info
Metabolic Type Oxidation - N-desethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007386 CBL-0102 CBL-0102 M2 Oxidation - N-desethylation CBL-0102 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007389 CBL-0102 M2 CBL-0102 M4 Oxidation - O-demethylation CBL-0102 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007388 CBL-0102 M3 CBL-0102 M5 Oxidation - Oxidationn CBL-0102 [1]
References
1 Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul;34(7):1136-44.

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