Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007386)
Formula
CYP3A4 ...
SVG example
N-desethylation
Reactant CBL-0102 Product CBL-0102 M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-desethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007390 CBL-0102 CBL-0102 M1 Unclear CBL-0102 [1]
MR007392 CBL-0102 CBL-0102 M6 Unclear CBL-0102 [1]
MR007393 CBL-0102 Unclear Oxidation - N-desethylation CBL-0102 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007387 CBL-0102 M2 CBL-0102 M3 Oxidation - N-desethylation CBL-0102 [1]
MR007389 CBL-0102 M2 CBL-0102 M4 Oxidation - O-demethylation CBL-0102 [1]
References
1 Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul;34(7):1136-44.
2 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.

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