Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007423)
Formula
SVG example
Reactant CP-122721 Product CP-677623
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A (CYP3A) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007417 CP-122721 CP-125611 Oxidation - O-demethylation CP-122721 [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007424 CP-677623 CP-919230 Oxidation - O-demethylation CP-122721 [1], [2]
References
1 In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49.
2 Metabolism, pharmacokinetics, and excretion of the substance P receptor antagonist CP-122,721 in humans: structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by high-performance liquid chromatography-tandem mass spectrometry and NMR spectroscopy

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