Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007435)
Formula Reactant CYC-202 Product CYC-202 M6
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007428 CYC-202 CYC-202 M1 Oxidation - Oxidationn CYC-202 [1]
MR007429 CYC-202 CYC-202 M2 Oxidation - N-dealkylation CYC-202 [1]
MR007430 CYC-202 CYC-202 M3 Oxidation - Oxidationn CYC-202 [1]
MR007431 CYC-202 CYC-202 M4 Oxidation - N-dealkylation CYC-202 [1]
MR007432 CYC-202 CYC-202 M5 Oxidation - Oxidationn CYC-202 [1]
MR007436 CYC-202 CYC-202 M7 Unclear CYC-202 [1]
MR007433 CYC-202 Met-4 Unclear CYC-202 [1]
MR007434 CYC-202 PMF30-128 Unclear CYC-202 [1]
References
1 Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (R-roscovitine) in vitro and in vivo. Drug Metab Dispos. 2008 Mar;36(3):561-70.

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