Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007570)
Formula
CBR1 ...
SVG example
Reactant BRN-3548355 Product NNAL
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 1 (CBR1) DME Info
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info
Aldo-keto reductase 1C4 (AKR1C4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007572 BRN-3548355 BRN-3548355 reactive intermediates Unclear BRN-3548355 [1]
MR007573 BRN-3548355 Unclear Unclear BRN-3548355 [2]
MR014091 BRN-3548355 Unclear Unclear BRN-3548355 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002959 Nicotine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol Unclear Nicotine [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007571 NNAL NNAL-glucuronide Unclear BRN-3548355 [1]
References
1 Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48.
2 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma
3 DrugBank(Pharmacology-Metabolism)Nicotine

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