Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007577)
Formula
SVG example
Hydrolyzationn
Reactant Bufuralol Product 1'-Hydroxybufuralol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007581 Bufuralol 1'2'-Ethenylbufuralol Unclear Bufuralol [1]
MR007578 Bufuralol 4-hydroxybufuralol Oxidation - Hydrolyzationn Bufuralol [2]
MR007579 Bufuralol 6-hydroxybufuralol Oxidation - Hydrolyzationn Bufuralol [2]
MR007580 Bufuralol Unclear Unclear Bufuralol [3]
References
1 S73 | METXBIODB | Metabolite:Bufuralol
2 Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes
3 The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6

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