Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007589)
Formula
SVG example
Hydrolyzationn
Reactant Butyrfentanyl Product (omega-1)-hydroxy-butyrylfentanyl
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007586 Butyrfentanyl 4'-hydroxy-butyrylfentanyl Oxidation - Hydrolyzationn Butyrfentanyl [1]
MR007588 Butyrfentanyl Beta-hydroxy-butyrylfentanyl Oxidation - Hydrolyzationn Butyrfentanyl [1]
MR007590 Butyrfentanyl Nor-butyrylfentanyl Unclear Butyrfentanyl [1]
MR007584 Butyrfentanyl Omega-hydroxy-butyrylfentany Oxidation - Hydrolyzationn Butyrfentanyl [1], [2]
References
1 Metabolism of butyrylfentanyl in fresh human hepatocytes: chemical synthesis of authentic metabolite standards for definitive identification. Biol Pharm Bull. 2019;42(4):623-630.
2 Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Drug Test Anal. 2017 Jul;9(7):1085-1092.

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