Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007668)
Formula
UGT
SVG example
Glucuronidation
Reactant Benzotetronic acid Product RS-8359 Glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007652 Benzotetronic acid 17-noraphidicolinone Unclear Benzotetronic acid [1]
MR007651 Benzotetronic acid 18-noraphidicolinone isomers Unclear Benzotetronic acid [1]
MR007664 Benzotetronic acid 2-Keto Oxidation - Oxidationn Benzotetronic acid [2]
MR007650 Benzotetronic acid 3-ketoaphidicolin Unclear Benzotetronic acid [1]
MR007666 Benzotetronic acid Cis-Diol Oxidation - Hydrolyzationn Benzotetronic acid [2]
MR007669 Benzotetronic acid Trans-Diol Oxidation - Hydrolyzationn Benzotetronic acid [2]
References
1 The mechanism of aphidicolin bioinactivation by rat liver in vitro systems. Xenobiotica. 1990 Mar;20(3):273-87.
2 Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes. Chirality. 2005 Mar;17(3):135-41.

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