Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007826)
Formula
SVG example
Hydrolysis
Reactant Carfilzomib Product Carfilzomib metabolite M16
Reactant Info Product Info
Metabolic Enzyme Epoxide hydrolase 1 (EPHX1) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007831 Carfilzomib Carfilzomib metabolite M14 Hydrolysis - Peptide hydrolysis Carfilzomib [1]
MR007830 Carfilzomib Carfilzomib metabolite M15 Hydrolysis - Peptide hydrolysis Carfilzomib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007829 Carfilzomib metabolite M16 Carfilzomib metabolite M14 Unclear - Unclear Carfilzomib [1]
MR007827 Carfilzomib metabolite M16 Carfilzomib metabolite M15 Unclear - Unclear Carfilzomib [1]
References
1 Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism Int J Mol Sci. 2021 Oct 27;22(21):11595. doi: 10.3390/ijms222111595.

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