Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007829)
Formula
SVG example
Unclear
Reactant Carfilzomib metabolite M16 Product Carfilzomib metabolite M14
Reactant Info Product Info
Metabolic Enzyme Cathepsin A (CTSA) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007826 Carfilzomib Carfilzomib metabolite M16 Hydrolysis - Hydrolysis Carfilzomib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007827 Carfilzomib metabolite M16 Carfilzomib metabolite M15 Unclear - Unclear Carfilzomib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007831 Carfilzomib Carfilzomib metabolite M14 Hydrolysis - Peptide hydrolysis Carfilzomib [1]
MR007828 Carfilzomib metabolite M15 Carfilzomib metabolite M14 Unclear - Unclear Carfilzomib [2]
References
1 Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism Int J Mol Sci. 2021 Oct 27;22(21):11595. doi: 10.3390/ijms222111595.
2 Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats

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