Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008324)
Formula
SVG example
Glucuronidation
Reactant PF-04991532 Product PF-04991532 metabolite M1
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008325 PF-04991532 PF-04991532 metabolite M3 Unclear - Unclear PF-04991532 [1]
MR008326 PF-04991532 PF-04991532 metabolite M4 Oxidation - Hydroxylation PF-04991532 [1]
MR008327 PF-04991532 PF-04991532 metabolite M5 Oxidation - Hydroxylation PF-04991532 [1]
References
1 Metabolism and excretion of (S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies

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