Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008451)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant DA-1229 Product 4S-Hydroxyevogliptin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008454 DA-1229 4R-Hydroxyevogliptin Oxidation - Hydroxylation DA-1229 [1]
MR008456 DA-1229 Evogliptin sulfate Conjugation - Sulfation DA-1229 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008453 4S-Hydroxyevogliptin 4-Oxoevogliptin Unclear - Unclear DA-1229 [1]
MR008452 4S-Hydroxyevogliptin 4S-Hydroxyevogliptin glucuronide Conjugation - Glucuronidation DA-1229 [1]
References
1 In Vitro Metabolic Pathways of the New Anti-Diabetic Drug Evogliptin in Human Liver Preparations

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