Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008588)
Formula
SVG example
Hydrolysis
Reactant Puerarin Product Puerarin metabolite M50
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008598 Puerarin Daidzein-4',7'-di-O-sulfate Conjugation - Sulfation Puerarin [1]
MR008599 Puerarin Daidzein-4'-O-sulfate Conjugation - Sulfation Puerarin [1]
MR008592 Puerarin Puerarin metabolite M21 Oxidation - Hydroxylation Puerarin [2]
MR008595 Puerarin Puerarin metabolite M37 Unclear - Unclear Puerarin [2]
MR008596 Puerarin Puerarin metabolite M4 Unclear - Unclear Puerarin [2]
MR008597 Puerarin Puerarin-4'-O-glucuronide Conjugation - Glucuronidation Puerarin [1]
MR008594 Puerarin Puerarin-7-O-glucuronide Conjugation - Glucuronidation Puerarin [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006104 CCRIS-1920 Metabolite M1 CCRIS-1920 Metabolite M2 Unclear CCRIS-1920 [4], [5]
MR006106 CCRIS-1920 Metabolite M3 CCRIS-1920 Metabolite M2 Unclear CCRIS-1920 [4], [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008589 Puerarin metabolite M50 Dihydrodaidzein Reduction - Reduction Puerarin [1]
MR008591 Puerarin metabolite M50 Puerarin metabolite M63 Unclear - Unclear Puerarin [2]
References
1 Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine
2 Rapid profiling and identification of puerarin metabolites in rat urine and plasma after oral administration by UHPLC-LTQ-Orbitrap mass spectrometer
3 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes
4 Cytochromes P450 and experimental models of drug metabolism. J Cell Mol Med. 2002 Apr-Jun;6(2):189-98.
5 Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.