Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008692)
Formula
SVG example
O-methylation
Reactant Alpha-methyldopamine Product 3-O-methyl-alpha-methyldopamine
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010012 Methyldopa Alpha-METHYLDOPAMINE Reduction - Decarboxylation Methyldopa [1]
MR008689 Methyldopate Hydrochloride Alpha-methyldopamine Reduction - Decarboxylation Methyldopate Hydrochloride [2], [3], [4], [5]
MR007406 HHMA HHA Oxidation - N-dealkylation CCRIS-9277 [6]
MR007395 MDA HHA Oxidation - O-demethylation CCRIS-9277 [6]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010013 Alpha-METHYLDOPAMINE Alpha-METHYLDOPAMINE SULFATE Unclear - Unclear Methyldopa [1]
MR008690 Alpha-methyldopamine Alpha-methylnorepinephrine Oxidation - Hydroxylation Methyldopate Hydrochloride [7]
MR007400 HHA CCRIS-9277 M4 Oxidation - Deamination CCRIS-9277 [6]
MR007402 HHA CCRIS-9277 M6 Conjugation - Sulfation CCRIS-9277 [6]
MR007407 HHA CCRIS-9277 M9 Conjugation - Sulfation CCRIS-9277 [6]
MR007396 HHA HMA Oxidation - Deamination CCRIS-9277 [6]
References
1 Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Clin Pharmacol Ther. 1984 Jan;35(1):55-63.
2 Antihypertensive metabolites of alpha-methyldopa
3 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.
4 The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects
5 THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS
6 Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44.
7 DrugBank(Pharmacology-Metabolism):Methyldopate Hydrochloride

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