Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008689)
Formula
DDC
SVG example
Decarboxylation
Reactant Methyldopate Hydrochloride Product Alpha-methyldopamine
Reactant Info Product Info
Metabolic Enzyme DOPA decarboxylase (DDC) DME Info
Metabolic Type Reduction - Decarboxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008695 Methyldopate Hydrochloride 3,4-Dihydroxyphenylacetone Multi-steps Reaction - Deamination; decarboxylation Methyldopate Hydrochloride [1], [2], [3]
MR008693 Methyldopate Hydrochloride 3-O-methyl-alpha-methyldopa Conjugation - O-methylation Methyldopate Hydrochloride [4], [5], [1]
MR008697 Methyldopate Hydrochloride Alpha-methyldopa-mono-O-sulfate Conjugation - Sulfation Methyldopate Hydrochloride [1], [2], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010012 Methyldopa Alpha-METHYLDOPAMINE Reduction - Decarboxylation Methyldopa [6]
MR007406 HHMA HHA Oxidation - N-dealkylation CCRIS-9277 [7]
MR007395 MDA HHA Oxidation - O-demethylation CCRIS-9277 [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008692 Alpha-methyldopamine 3-O-methyl-alpha-methyldopamine Conjugation - O-methylation Methyldopate Hydrochloride [8]
MR010013 Alpha-METHYLDOPAMINE Alpha-METHYLDOPAMINE SULFATE Unclear - Unclear Methyldopa [6]
MR008690 Alpha-methyldopamine Alpha-methylnorepinephrine Oxidation - Hydroxylation Methyldopate Hydrochloride [8]
MR007400 HHA CCRIS-9277 M4 Oxidation - Deamination CCRIS-9277 [7]
MR007402 HHA CCRIS-9277 M6 Conjugation - Sulfation CCRIS-9277 [7]
MR007407 HHA CCRIS-9277 M9 Conjugation - Sulfation CCRIS-9277 [7]
MR007396 HHA HMA Oxidation - Deamination CCRIS-9277 [7]
⏷ Show the Full List of MR
References
1 THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS
2 Clinical pharmacokinetics of methyldopa
3 Reaction of dopa decarboxylase with alpha-methyldopa leads to an oxidative deamination producing 3,4-dihydroxyphenylacetone, an active site directed affinity label
4 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.
5 The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects
6 Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Clin Pharmacol Ther. 1984 Jan;35(1):55-63.
7 Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44.
8 DrugBank(Pharmacology-Metabolism):Methyldopate Hydrochloride

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.