Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008694)
Formula Reactant 3-O-methyl-alpha-methyldopa Product 3-O-methyl-alpha-methyldopa sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase (SULT) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001500 Levodopa 3-O-Methyldopa Conjugation - Methylation Levodopa [1], [2], [3], [4]
MR008693 Methyldopate Hydrochloride 3-O-methyl-alpha-methyldopa Conjugation - O-methylation Methyldopate Hydrochloride [5], [6], [7]
References
1 Motor complications, levodopa metabolism and progression of Parkinson's disease Expert Opin Drug Metab Toxicol. 2011 Jul;7(7):847-55. doi: 10.1517/17425255.2011.575779.
2 Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of L-dopa and its metabolite 3-O-methyldopa in combination with entacapone. J Neural Transm (Vienna). 2021 Jan;128(1):27-36. doi: 10.1007/s00702-020-02267-y.
3 Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia. Sci Adv. 2021 Jan 6;7(2):eabe5948. doi: 10.1126/sciadv.abe5948. Print 2021 Jan.
4 Pharmacokinetics of Levodopa and 3-O-Methyldopa in Parkinsonian Patients Treated with Levodopa and Ropinirole and in Patients with Motor Complications. Pharmaceutics. 2021 Sep 3;13(9):1395. doi: 10.3390/pharmaceutics13091395.
5 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.
6 The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects
7 THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS

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