Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008709)
Formula
SVG example
Unclear
Reactant Imidapril Product Imidaprilat
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008714 Imidapril Imidapril Metabolite M2 Unclear - Unclear Imidapril [1]
MR008712 Imidapril Imidapril Metabolite M3 Unclear - Unclear Imidapril [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006471 TA-6366 Imidaprilat Hydrolysis - Hydrolysis TA-6366 [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008711 Imidaprilat Imidapril Metabolite M2 Unclear - Unclear Imidapril [4]
MR008710 Imidaprilat Imidapril Metabolite M4 Unclear - Unclear Imidapril [4]
References
1 Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 7th communication: in vitro metabolism
2 Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 5th communication: isolation and identification of metabolites of imidapril in rats, dogs, and monkeys
3 Inhibition of human liver carboxylesterase (hCE1) by organophosphate ester flame retardants and plasticizers: implications for pharmacotherapy. Toxicol Sci. 2019 Jul 3. pii: kfz149.
4 Radioimmunoassay for imidapril, a new angiotensin-converting enzyme inhibitor, and imidaprilat, its active metabolite, in human plasma and urine

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