Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008757)
Formula
SVG example
Esterase hydrolysis
Reactant Acetylbenzocaine Product 4-Acetaminobenzoic acid
Reactant Info Product Info
Metabolic Type Hydrolysis - Esterase hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008756 Benzocaine Acetylbenzocaine Conjugation - Acetylation Benzocaine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004151 Aminobenzoic acid N-acetyl-p-aminobenzoic acid Conjugation - N-acetylation Aminobenzoic acid [2]
MR008755 Aminobenzoic acid 4-Acetaminobenzoic acid Conjugation - Acetylation Benzocaine [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004152 N-acetyl-p-aminobenzoic acid p-acetamidohippuric acid (PAAHA) Unclear Aminobenzoic acid [4]
References
1 More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems
2 Human placental transfer and metabolism of p-aminobenzoic acid
3 Metabolism and elimination of benzocaine by rainbow trout, Oncorhynchus mykiss
4 Metabolic kinetics of p-aminobenzoic acid in rabbits

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