Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008773)
Formula
SVG example
Unclear
Reactant Didanosine Product Uric acid
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008775 Didanosine 2,3-dideoxyadenosine-5-triphosphate Unclear - Unclear Didanosine [1]
MR008771 Didanosine Hypoxanthine Unclear - Unclear Didanosine [2]
MR008774 Didanosine Xanthine Unclear - Unclear Didanosine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000085 Adenosine-c-phosphate Uric acid Unclear Adenosine-c-phosphate [3]
MR006316 Fructose Uric acid Unclear Fructose [4]
MR007055 Hypoxanthine Uric acid Conjugation - Glucuronidation Hypoxanthine [5]
MR004031 Xanthine Uric acid Unclear Xanthine [6], [7]
MR008772 Hypoxanthine Uric acid Unclear - Unclear Didanosine [2]
MR007509 Xanthine Uric acid Unclear Inosine [8]
MR000079 Xanthine Uric acid Oxidation - Oxidation Adenosine [9], [10]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004032 Uric acid Allantoin Unclear Xanthine [7]
MR007510 Uric acid Allantion Unclear Inosine [8]
References
1 DrugBank(Pharmacology-Metabolism):Didanosine
2 Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes
3 Transport and metabolism of N6- and C8-substituted analogs of adenosine 3',5'-cyclic monophosphate and adenosine 3'5'-cyclic phosphorothioate by the isolated perfused rat kidney Life Sci. 1983 Mar 28;32(13):1489-98. doi: 10.1016/0024-3205(83)90915-3.
4 High fructose diet: A risk factor for immune system dysregulation
5 T3DB:Hypoxanthine
6 Xanthine oxidoreductase activity is correlated with hepatic steatosis
7 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism
8 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos
9 Adenosine Metabolism: Emerging Concepts for Cancer Therapy Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007.
10 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.

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