Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008779)
Formula
SVG example
Hydrolysis
Reactant Vildagliptin Product Vildagliptin M20.7 metabolite
Reactant Info Product Info
Metabolic Enzyme Dipeptidyl peptidase IV (DPP4) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008780 Vildagliptin Vildagliptin M15.3 metabolite Hydrolysis - Amide Hydrolysis Vildagliptin [1], [2]
MR008781 Vildagliptin Vildagliptin M20.2 metabolite Conjugation - Glucuronidation Vildagliptin [1], [2], [3]
MR008782 Vildagliptin Vildagliptin M20.9 metabolite Oxidation - Oxidation Vildagliptin [1], [2]
MR008783 Vildagliptin Vildagliptin M21.6 metabolite Reduction - Decarboxylation Vildagliptin [1], [2]
MR008785 Vildagliptin Vildagliptin metabolite M14.2 Unclear - Unclear Vildagliptin [2]
MR008784 Vildagliptin Vildagliptin metabolite M18.6 Unclear - Unclear Vildagliptin [2]
References
1 Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans
2 Disposition of vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in rats and dogs
3 Dipeptidyl peptidase-4 greatly contributes to the hydrolysis of vildagliptin in human liver

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