Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008780)
Formula
SVG example
Amide Hydrolysis
Reactant Vildagliptin Product Vildagliptin M15.3 metabolite
Reactant Info Product Info
Metabolic Type Hydrolysis - Amide Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008781 Vildagliptin Vildagliptin M20.2 metabolite Conjugation - Glucuronidation Vildagliptin [1], [2], [3]
MR008779 Vildagliptin Vildagliptin M20.7 metabolite Hydrolysis - Hydrolysis Vildagliptin [1], [2], [3]
MR008782 Vildagliptin Vildagliptin M20.9 metabolite Oxidation - Oxidation Vildagliptin [1], [2]
MR008783 Vildagliptin Vildagliptin M21.6 metabolite Reduction - Decarboxylation Vildagliptin [1], [2]
MR008785 Vildagliptin Vildagliptin metabolite M14.2 Unclear - Unclear Vildagliptin [2]
MR008784 Vildagliptin Vildagliptin metabolite M18.6 Unclear - Unclear Vildagliptin [2]
References
1 Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans
2 Disposition of vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in rats and dogs
3 Dipeptidyl peptidase-4 greatly contributes to the hydrolysis of vildagliptin in human liver

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