General Information of This Metabolic Reaction (MR) (ID: MR008842)
Formula
SVG example
N-dearylation
Reactant Ivosidenib Product Ivosidenib metabolite M44
Reactant Info Product Info
Metabolic Type Oxidation - N-dearylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008841 Ivosidenib Ivosidenib M30 metabolite Oxidation - N-dealkylation Ivosidenib [1]
MR008839 Ivosidenib Ivosidenib M39 metabolite Hydrolysis - Hydrolysis Ivosidenib [1]
MR008843 Ivosidenib Ivosidenib metabolite M5 Unclear - Unclear Ivosidenib [2]
MR008844 Ivosidenib Ivosidenib metabolite M6 Unclear - Unclear Ivosidenib [2]
References
1 Pharmacokinetics, absorption, metabolism, and excretion of [(14)C]ivosidenib (AG-120) in healthy male subjects
2 Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.