Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR008844)
Formula	Unclear
	Reactant	Ivosidenib		Product	Ivosidenib metabolite M6
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Unclear - Unclear

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR008841	Ivosidenib	Ivosidenib M30 metabolite	Oxidation - N-dealkylation	Ivosidenib	[1]
MR008839	Ivosidenib	Ivosidenib M39 metabolite	Hydrolysis - Hydrolysis	Ivosidenib	[1]
MR008842	Ivosidenib	Ivosidenib metabolite M44	Oxidation - N-dearylation	Ivosidenib	[1]
MR008843	Ivosidenib	Ivosidenib metabolite M5	Unclear - Unclear	Ivosidenib	[2]

References
1	Pharmacokinetics, absorption, metabolism, and excretion of [(14)C]ivosidenib (AG-120) in healthy male subjects
2	Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies

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