Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009246)
Formula
CES1 ...
SVG example
Hydrolysis
Reactant Beclomethasone dipropionate Product Beclomethasone-17-monopropionate (17-BMP)
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Arylacetamide deacetylase (AADAC) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A43 (CYP3A43) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009253 Beclomethasone dipropionate 6beta-OH-BDP Unclear - Unclear Beclomethasone dipropionate [1]
MR009251 Beclomethasone dipropionate Beclomethasone-21-monopropionate (21-BMP) Hydrolysis - Hydrolysis Beclomethasone dipropionate [2]
MR009254 Beclomethasone dipropionate Delta6-BDP Unclear - Unclear Beclomethasone dipropionate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009252 Beclomethasone-17-monopropionate (17-BMP) Beclomethasone dipropionate Metabolite D-2 Hydrolysis - Esterase hydrolysis Beclomethasone dipropionate [2]
MR009247 Beclomethasone-17-monopropionate (17-BMP) Beclomethasone-21-monopropionate (21-BMP) Unclear - Unclear Beclomethasone dipropionate [2]
References
1 Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16.
2 Comparative kinetics of metabolism of beclomethasone propionate esters in human lung homogenates and plasma

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