Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009515)
Formula
SVG example
Methylhydroxylation
Reactant Regorafenib M2 Product Regorafenib M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Methylhydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009514 Regorafenib Regorafenib M2 Oxidation - N-oxidation Regorafenib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009517 Regorafenib M2 Regorafenib M5 Oxidation - N-demethylation Regorafenib [1], [2]
MR009518 Regorafenib M2 Regorafenib M8 Conjugation - Glucuronidation Regorafenib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009520 Regorafenib M3 Regorafenib M1 Multi-steps Reaction - N-oxidation; methylhydroxylation Regorafenib [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009516 Regorafenib M1 Regorafenib M5 Oxidation - Demethylation Regorafenib [2]
References
1 Quantification of cobimetinib, cabozantinib, dabrafenib, niraparib, olaparib, vemurafenib, regorafenib and its metabolite regorafenib M2 in human plasma by UPLC-MS/MS
2 Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects

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