Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009521)
Formula Reactant Regorafenib M3 Product Regorafenib M4
Reactant Info Product Info
Metabolic Enzyme Alcohol dehydrogenase (ADH) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009519 Regorafenib Regorafenib M3 Oxidation - Hydroxylation Regorafenib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009520 Regorafenib M3 Regorafenib M1 Multi-steps Reaction - N-oxidation; methylhydroxylation Regorafenib [1]
MR009523 Regorafenib M3 Regorafenib M6 Oxidation - Oxidation Regorafenib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009522 Regorafenib M4 Regorafenib M6 Oxidation - Oxidation Regorafenib [1]
References
1 Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects

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