Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009574)
Formula
SVG example
4-hydroxylation
Reactant PPX Product 4-OH-PPX
Reactant Info Product Info
Metabolic Type Oxidation - 4-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009572 Ropivacaine hydrochloride PPX Oxidation - N-dealkylation Ropivacaine hydrochloride [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009573 PPX 3-OH-PPX Oxidation - 3-hydroxylation Ropivacaine hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009571 4-Hydroxyropivacaine 4-OH-PPX Oxidation - N-dealkylation Ropivacaine hydrochloride [3]
References
1 Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine. J Pharm Pharmacol. 2003 Jul;55(7):963-72.
2 Effect of propofol on ropivacaine metabolism in human liver microsomes
3 LABEL:Ropivacaine hydrochloride

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