Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009572)
Formula
SVG example
N-dealkylation
Reactant Ropivacaine hydrochloride Product PPX
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009575 Ropivacaine hydrochloride 2-Hydroxymethylropivacaine Oxidation - Methylhydroxylation Ropivacaine hydrochloride [1]
MR009568 Ropivacaine hydrochloride 3-hydroxyropivacaine Oxidation - 3-hydroxylation Ropivacaine hydrochloride [2]
MR009570 Ropivacaine hydrochloride 4-Hydroxyropivacaine Oxidation - 4-hydroxylation Ropivacaine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009573 PPX 3-OH-PPX Oxidation - 3-hydroxylation Ropivacaine hydrochloride [3]
MR009574 PPX 4-OH-PPX Oxidation - 4-hydroxylation Ropivacaine hydrochloride [3]
References
1 Metabolism and excretion of ropivacaine in humans
2 Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column
3 LABEL:Ropivacaine hydrochloride

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