Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009731)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Motesanib Product Motesanib M1
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009732 Motesanib Motesanib M3 Unclear - Unclear Motesanib [1]
MR009726 Motesanib Motesanib M4 Unclear - Unclear Motesanib [1], [2]
MR009723 Motesanib Motesanib M5 Oxidation - Hydroxylation Motesanib [1]
MR009729 Motesanib Motesanib Ma Unclear - Unclear Motesanib [1]
MR009730 Motesanib Motesanib Mb Unclear - Unclear Motesanib [1]
MR009727 Motesanib Motesanib Mv Unclear - Unclear Motesanib [1]
MR009733 Motesanib Motesanib Mx Unclear - Unclear Motesanib [1]
References
1 In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans
2 Population pharmacokinetic modeling of motesanib and its active metabolite, M4, in cancer patients

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