Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009723)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Motesanib Product Motesanib M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009731 Motesanib Motesanib M1 Conjugation - Glucuronidation Motesanib [1]
MR009732 Motesanib Motesanib M3 Unclear - Unclear Motesanib [1]
MR009726 Motesanib Motesanib M4 Unclear - Unclear Motesanib [1], [2]
MR009729 Motesanib Motesanib Ma Unclear - Unclear Motesanib [1]
MR009730 Motesanib Motesanib Mb Unclear - Unclear Motesanib [1]
MR009727 Motesanib Motesanib Mv Unclear - Unclear Motesanib [1]
MR009733 Motesanib Motesanib Mx Unclear - Unclear Motesanib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009724 Motesanib M5 Motesanib M4 Unclear - Unclear Motesanib [1]
References
1 In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans
2 Population pharmacokinetic modeling of motesanib and its active metabolite, M4, in cancer patients

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