Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009848)
Formula
SVG example
Unclear
Reactant Alprazolam Product Alpha-hydroxyalprazolam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A43 (CYP3A43) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009846 Alprazolam 4-hydroxyalprazolam Unclear - Unclear Alprazolam [1], [2]
MR009844 Alprazolam 5-N-O?alprazolam Unclear - Unclear Alprazolam [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002799 Adinazolam Alpha-hydroxyalprazolam Unclear Adinazolam [4]
References
1 Alprazolam metabolism in vitro: studies of human, monkey, mouse, and rat liver microsomes
2 Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite
3 Changes in Alprazolam Metabolism by CYP3A43 Mutants
4 Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998 Mar;50(3):265-74.

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