Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009871)
Formula
SVG example
Unclear
Reactant Atomoxetine hydrochloride Product 4-hydroxyatomoxetine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009862 Atomoxetine hydrochloride Atomoxetine hydrochloride Metabolite M1 Unclear - Unclear Atomoxetine hydrochloride [1]
MR009868 Atomoxetine hydrochloride N-desmethylatomoxetine Unclear - Unclear Atomoxetine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009872 4-hydroxyatomoxetine 4-hydroxyatomnoxetine-O-glucuronide Conjugation - Glucuronidation Atomoxetine hydrochloride [1]
References
1 Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism
2 Atomoxetine: a review of its pharmacokinetics and pharmacogenomics relative to drug disposition. J Child Adolesc Psychopharmacol. 2016 May;26(4):314-26.

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