Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009875)
Formula
SVG example
Unclear
Reactant Atorvastatin calcium Product 4-hydroxyatorvastatin acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009873 Atorvastatin calcium 2-hydroxyatorvastatin acid Unclear - Unclear Atorvastatin calcium [1], [2]
MR009877 Atorvastatin calcium Atorvastatin lactone Conjugation - Lactonization Atorvastatin calcium [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009876 4-hydroxyatorvastatin acid 4-hydroxyatorvastatin lactone Conjugation - Lactonization Atorvastatin calcium [3]
References
1 Influence of Drug-Drug Interactions on the Pharmacokinetics of Atorvastatin and Its Major Active Metabolite ortho-OH-Atorvastatin in Aging People Living with HIV
2 Development of an LC-MS/MS method for simultaneous determination of ticagrelor and its active metabolite during concomitant treatment with atorvastatin
3 Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

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