Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009879)
Formula
SVG example
Unclear
Reactant Atorvastatin lactone Product 4-hydroxyatorvastatin lactone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009877 Atorvastatin calcium Atorvastatin lactone Conjugation - Lactonization Atorvastatin calcium [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009878 Atorvastatin lactone 2-hydroxyatorvastatin lactone Unclear - Unclear Atorvastatin calcium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009876 4-hydroxyatorvastatin acid 4-hydroxyatorvastatin lactone Conjugation - Lactonization Atorvastatin calcium [1]
References
1 Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

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