Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009991)
Formula Reactant Metamfetamine Product p-hydroxymethamphetamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009984 Metamfetamine Amphetamine Unclear - Unclear Metamfetamine [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010007 Methamphetamine hydrochloride p-hydroxymethamphetamine Unclear - Unclear Methamphetamine hydrochloride [3], [4]
MR007173 Methamphetamine p-Hydroxymethamphetamine Oxidation - p-hydroxylation Famprofazone [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009992 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [6]
MR010008 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [6]
MR007174 p-Hydroxymethamphetamine p-Hydroxyamphetamine Oxidation - N-demethylation Famprofazone [5]
References
1 Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
2 Drugs of abuse in a non-conventional sample; detection of methamphetamine and its main metabolite, amphetamine in abusers' clothes by HPLC with UV and fluorescence detection
3 Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
4 Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia
5 Identification of new urinary metabolites of famprofazone in humans
6 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.