Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010015)
Formula
SVG example
O-methylation
Reactant Methyldopa Product 3-0-METHYL-a-METHYLDOPA
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010012 Methyldopa Alpha-METHYLDOPAMINE Reduction - Decarboxylation Methyldopa [1]
MR010014 Methyldopa METHYLDOPA SULFATE Conjugation - Sulfate conjugation Methyldopa [2]
References
1 Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Clin Pharmacol Ther. 1984 Jan;35(1):55-63.
2 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.

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