Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010030)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Raloxifene Product Raloxifene-6-bate-glucuronide(M1)
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010029 Raloxifene Raloxifen-4-glucoronide(M2) Conjugation - Glucuronidation Raloxifene [1], [2], [3]
MR010031 Raloxifene Raloxifene-6, 4-diglucuronide(M3) Conjugation - Glucuronidation Raloxifene [1], [2]
MR010032 Raloxifene Raloxifene-6-sulfate Unclear - Unclear Raloxifene [4]
References
1 Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9
2 Determination of raloxifene and its glucuronides in human urine by liquid chromatography-tandem mass spectrometry assay
3 Pharmacokinetics of raloxifene and its clinical application
4 Development and validation of ultra-high-performance liquid chromatography-mass spectrometry method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats

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