| General Information of Drug Metabolite (DM) (ID: DM018117) |
| DM Name |
Raloxifene-6, 4-diglucuronide(M3)
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A1 (UGT1A1)
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DME0004
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| Conjugation - Glucuronidation |
Raloxifene
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[1] , [2] |
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UDP-glucuronosyltransferase 1A10 (UGT1A10)
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DME0075
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| Conjugation - Glucuronidation |
Raloxifene
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[1] , [2] |
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UDP-glucuronosyltransferase 1A8 (UGT1A8)
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DME0064
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| Conjugation - Glucuronidation |
Raloxifene
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[1] , [2] |
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UDP-glucuronosyltransferase 1A9 (UGT1A9)
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DME0042
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| Conjugation - Glucuronidation |
Raloxifene
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Raloxifene |
DR1388
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Approved |
Osteoporosis |
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| References |
| 1 |
Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9
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| 2 |
Determination of raloxifene and its glucuronides in human urine by liquid chromatography-tandem mass spectrometry assay
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