Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010107)
Formula
SVG example
O-demethylation
Reactant PU-H71 Product PU-H71 Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010110 PU-H71 PU-H71 Metabolite M4 Oxidation - S-oxidation PU-H71 [1]
MR010111 PU-H71 PU-H71 Metabolite M5 Oxidation - N-dealkylation PU-H71 [1]
MR010112 PU-H71 PU-H71 Metabolite M6 Reduction - Deiodination PU-H71 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010108 PU-H71 Metabolite M1 PU-H71 Metabolite M2 Oxidation - O-demethylation PU-H71 [1]
References
1 First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile

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