Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010108)
Formula Reactant PU-H71 Metabolite M1 Product PU-H71 Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010107 PU-H71 PU-H71 Metabolite M1 Oxidation - O-demethylation PU-H71 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010109 PU-H71 Metabolite M2 PU-H71 Metabolite M3 Conjugation - Glucuronidation PU-H71 [1]
References
1 First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile

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