Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010978)
Formula
SVG example
Hydroxylation
Reactant Exjade Product Exjade Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A (CYP1A) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010979 Exjade Exjade Metabolite M2 Oxidation - Hydroxylation Exjade [1]
MR010977 Exjade Exjade Metabolite M3 Conjugation - O-glucuronidation Exjade [1]
MR010980 Exjade Exjade Metabolite M4 Oxidation - Hydroxylation Exjade [1]
MR010981 Exjade Exjade Metabolite M6 Conjugation - O-glucuronidation Exjade [1]
References
1 Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats Drug Metab Dispos. 2008 Dec;36(12):2523-38. doi: 10.1124/dmd.108.022962.

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