Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011374)
Formula
SVG example
O-dealkylation
Reactant Azilsartan Product TAK-491 Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008917 Azilsartan Azilsartan M-I Reduction - Decarboxylation Azilsartan [1]
MR013087 Azilsartan Azilsartan M- Reduction - Decarboxylation Azilsartan medoxomil [2]
MR011373 Azilsartan TAK-491 Metabolite M1 Reduction - Decarboxylation TAK-491 [1]
References
1 Development, validation and application of the liquid chromatography tandem mass spectrometry method for simultaneous quantification of azilsartan medoxomil (TAK-491), azilsartan (TAK-536), and its 2 metabolites in human plasma
2 Critical evaluation of the efficacy and tolerability of azilsartan

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.