Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008917)
Formula
CYP2C8 ...
SVG example
Decarboxylation
Reactant Azilsartan Product Azilsartan M-I
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Reduction - Decarboxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008918 Azilsartan Azilsartan M-II Oxidation - O-dealkylation Azilsartan [1], [2]
MR013088 Azilsartan Azilsartan M- Oxidation - O-dealkylation Azilsartan medoxomil [3]
MR011374 Azilsartan TAK-491 Metabolite M2 Oxidation - O-dealkylation TAK-491 [1]
References
1 Development, validation and application of the liquid chromatography tandem mass spectrometry method for simultaneous quantification of azilsartan medoxomil (TAK-491), azilsartan (TAK-536), and its 2 metabolites in human plasma
2 Lithium Intoxication in the Elderly: A Possible Interaction between Azilsartan, Fluvoxamine, and Lithium
3 Critical evaluation of the efficacy and tolerability of azilsartan

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