Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012187)
Formula
SVG example
Unclear
Reactant Hydroxychloroquine Product Bisdesethylchloroquine
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012186 Hydroxychloroquine Desethylhydroxychloroquine Unclear - Unclear Hydroxychloroquine [1]
MR012185 Hydroxychloroquine Monodesethylchloroquine Unclear - Unclear Hydroxychloroquine [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005142 Hydroxychloroquine sulfate Bidesethylchloroquine Oxidation - N-dealkylation Hydroxychloroquine sulfate [1], [4], [3]
References
1 Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax. Antimicrob Agents Chemother. 2009 Apr;53(4):1468-75.
2 The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects
3 Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters Curr Drug Metab. 2020;21(14):1127-1135. doi: 10.2174/1389200221999201208211537.
4 Hydroxychloroquine: a physiologically-based pharmacokinetic model in the context of cancer-related autophagy modulation. J Pharmacol Exp Ther. 2018 Jun;365(3):447-459.

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