General Information of This Metabolic Reaction (MR) (ID: MR012429)
Formula
SVG example
O-despiperidine
Reactant AZD8931 Product AZD8931 M18
Reactant Info Product Info
Metabolic Type Oxidation - O-despiperidine
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012436 AZD8931 AZD8931 M10 Other reaction - Hydroxy-chlorofluorophenylation AZD8931 [1]
MR012434 AZD8931 AZD8931 M11 Oxidation - Monooxygenation AZD8931 [1]
MR012427 AZD8931 AZD8931 M12 Oxidation - O-desmethylation AZD8931 [1]
MR012442 AZD8931 AZD8931 M13 Oxidation - N-desmethylation AZD8931 [1]
MR012439 AZD8931 AZD8931 M14 Conjugation - N-hydroxymethylation AZD8931 [1]
MR012441 AZD8931 AZD8931 M15 Other reaction - Hydroxypiperidine AZD8931 [1]
MR012443 AZD8931 AZD8931 M20 Unclear - N-acetic acid AZD8931 [1]
MR012432 AZD8931 AZD8931 M9 Oxidation - N-dealkylation AZD8931 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012431 AZD8931 M18 AZD8931 M1 Conjugation - O-despiperidinyl glucosidation AZD8931 [1]
MR012430 AZD8931 M18 AZD8931 M5 Conjugation - O-despiperidinyl sulfation AZD8931 [1]
References
1 Metabolic disposition of AZD8931, an oral equipotent inhibitor of EGFR, HER2 and HER3 signalling, in rat, dog and man

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